Nutrition Topics > Performance Enhancing Substances

Contributed by Thomas Higginbotham, D.O. & William Elliot, MS,
FT, CFT, CNMT, LMT

Important Facts:

• Performance enhancing drugs take many forms. Ergogenic aids are actively sought by athletes of all classes.
• Recent references cite as much as 11% of high school students may have used steroids. Little validation exists for the purported claims of performance enhancing substances.
• Any substance taken with the intent to improve performance needs to be carefully reviewed with one’s medical history. Drug/ergogenic aids interactions occur.

General Information
There is heightened interest in factors that enhance capacity for exercise, training and competition. Performance enhancing substances, otherwise known as ergogenic aids, refer to the application of a nutritional substance or medication or diet practice to improve physical work capacity, athletic performance, and responsiveness to exercise training.

Considerable literature exists concerning the ergogenic effect of nutritional and pharmacologic aids on exercise performance and training. Unfortunately, many claims are frequently unsubstantiated. With the aggressive marketing, it is no surprise that exercise enthusiasts, competitive athletes and their coaches often fall prey to the lore of the latest fad.

Mechanism for How Purported Ergogenic Aids Might Work Include the Following:

1. Act as a central peripheral stimulant to the nervous system (i.e. caffeine, choline, amphetamines, alcohol).
2. Increase the storage and/or availability of a limiting substrate (such as carbohydrate loading, creatine, carnitine, chromium).
3. Act as supplemental fuel source (i.e. glucose, medium chain triglycerides).
4. Reduce or neutralize performance inhibiting metabolic byproducts (i.e. sodium, bicarbonate, sodium phosphate, sodium citrate, pangamic acid).
5. Enhance strength through their anabolic effects (steroids, human growth hormone).
6. Facilitate recovery (such as high glycemic carbohydrates, water).

Note: Table Guide:
Type refers to the aforementioned mechanisms of action.
Purported Effect refers to the medical and non-medical claims of benefit as a performance enhancing substance.
Substantial physio refers to the strength of validity from clinical and scientific research of the purported effects on the body’s physiology.
Substantial ergogenic refers to the strength of validity of the performance enhancing effects based on clinical and scientific research.
Banned refers to the prohibition of the use during NCAA and Olympic competition.
Adverse Effects/Problems refers to the more commonly associated side effects and interactions reported in the medical and scientific literature.

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